(R)-citramalate synthase explained

(R)-citramalate synthase
Ec Number:	2.3.1.182

(R)-citramalate synthase (CimA) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

acetyl-CoA + pyruvate + H₂O

\rightleftharpoons CoA + (2R)-2-hydroxy-2-methylbutanedioate

This enzyme participates in a novel pyruvate pathway for isoleucine biosynthesis.

Notes and References

1. Howell DM, Xu H, White RH . (R)-citramalate synthase in methanogenic archaea . Journal of Bacteriology . 181 . 1 . 331–3 . January 1999 . 9864346 . 103565 .
2. Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G . Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway . Journal of Bacteriology . 186 . 16 . 5400–9 . August 2004 . 15292141 . 490871 . 10.1128/jb.186.16.5400-5409.2004 .