(R)-4-hydroxyphenyllactate dehydrogenase explained

(R)-4-hydroxyphenyllactate dehydrogenase
Ec Number:	1.1.1.222
Cas Number:	101754-02-3
Go Code:	0047029

(R)-4-hydroxyphenyllactate dehydrogenase is an enzyme that catalyzes a chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+

\rightleftharpoons 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD, and NADP, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P) 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.

References

• Bode R, Lippoldt A, Birnbaum D . 1986 . Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa . Biochem. Physiol. Pflanzen . 181 . 189 - 198 .
• Leelayoova S, Marbury D, Rainey PM, Mackenzie NE, Hall JE . In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes . J. Protozool. . 39 . 2 . 350–8 . 1992 . 1578411 . 10.1111/j.1550-7408.1992.tb01329.x.