(R)-3-Nitrobiphenyline Explained

(R)-3-Nitrobiphenyline is a drug which acts as an α-adrenergic agonist, selective for the α subtype, as well as being a weak antagonist at the α and α subtypes. It has been used in scientific research to characterize the binding and functional properties of the α subtype.^{[1] [2]}

Notes and References

1. Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M . 6 . Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist . Journal of Medicinal Chemistry . 50 . 16 . 3964–3968 . August 2007 . 17630725 . 10.1021/jm061487a .
2. Del Bello F, Mattioli L, Ghelfi F, Giannella M, Piergentili A, Quaglia W, Cardinaletti C, Perfumi M, Thomas RJ, Zanelli U, Marchioro C, Dal Cin M, Pigini M . 6 . Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence . Journal of Medicinal Chemistry . 53 . 21 . 7825–7835 . November 2010 . 20925410 . 10.1021/jm100977d .