(R)-2-hydroxyacid dehydrogenase explained

(R)-2-hydroxyacid dehydrogenase
Ec Number:	1.1.1.272
Go Code:	0050578

In enzymology, a (R)-2-hydroxyacid dehydrogenase is an enzyme that catalyzes the chemical reaction

(2R)-3-sulfolactate + NAD(P)

\rightleftharpoons 3-sulfopyruvate + NAD(P)H + H

The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, NAD, and NADP, whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and H. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran.^[1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-2-hydroxyacid:NAD(P) oxidoreductase. Other names in common use include (R)-sulfolactate:NAD(P) oxidoreductase, L-sulfolactate dehydrogenase, ComC, and (R)-sulfolactate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Graupner M, White RH . 2001 . The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea . Biochim. Biophys. Acta . 1548 . 169 - 73 . 11451450 . 1 . 10.1016/S0167-4838(01)00220-5 .
• Graham DE, White RH . 2002 . Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics . Nat. Prod. Rep. . 19 . 133 - 47 . 12013276 . 10.1039/b103714p . 2 .

Notes and References

1. Graupner M, Xu H, White RH . 2000 . Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea . J. Bacteriol. . 182 . 3688 - 92 . 10850983 . 10.1128/JB.182.13.3688-3692.2000 . 13 . 94539 .