(Phosphatase 2A protein)-leucine-carboxy methyltransferase explained

(phosphatase 2A protein)-leucine-carboxy methyltransferase
Ec Number:	2.1.1.233

(phosphatase 2A protein)-leucine-carboxy methyltransferase (leucine carboxy methyltransferase-1, LCMT1) is an enzyme with systematic name S-adenosyl-L-methionine:(phosphatase 2A protein)-leucine O-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine

\rightleftharpoons S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester

Methylates the C-terminal leucine of phosphatase 2A.

Notes and References

1. De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J . Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue . Biochemistry . 38 . 50 . 16539–47 . December 1999 . 10600115 . 10.1021/bi991646a .
2. Tsai ML, Cronin N, Djordjevic S . The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A . Acta Crystallographica Section D . 67 . Pt 1 . 14–24 . January 2011 . 21206058 . 10.1107/s0907444910042204 .