(Myelin basic protein)-arginine N-methyltransferase explained

[myelin basic protein]-arginine N-methyltransferase
Ec Number:	2.1.1.126
Cas Number:	9055-07-6
Go Code:	0016277

In enzymology, a [myelin basic protein]-arginine N-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [myelin basic protein]-arginine

\rightleftharpoons S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-arginine

Thus, the two substrates of this enzyme are S-adenosyl methionine and myelin basic protein-arginine, whereas its two products are S-adenosylhomocysteine and myelin basic protein-Nomega-methyl-arginine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[myelin-basic-protein]-arginine Nomega-methyltransferase. Other names in common use include myelin basic protein methylase I, protein methylase I, S-adenosyl-L-methionine:[myelin-basic-protein]-arginine, and omega-N-methyltransferase.

References

• Ghosh SK, Paik WK, Kim S . 1988 . Purification and molecular identification of two protein methylases I from calf brain. Myelin basic protein- and histone-specific enzyme . J. Biol. Chem. . 263 . 19024 - 33 . 2461933 . 35 .