(Histone-H3)-lysine-36 demethylase explained

(Histone-H3)-lysine-36 demethylase
Ec Number:	1.14.11.27

(Histone-H3)-lysine-36 demethylase (JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O₂

\rightleftharpoons protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO₂ (overall reaction)

(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O₂

\rightleftharpoons protein N6-methyl-L-lysine + succinate + formaldehyde + CO₂

(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2

\rightleftharpoons protein L-lysine + succinate + formaldehyde + CO₂

(Histone-H3)-lysine-36 demethylase contains iron(II).

Notes and References

1. Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y . Histone demethylation by a family of JmjC domain-containing proteins . Nature . 439 . 7078 . 811–6 . February 2006 . 16362057 . 10.1038/nature04433 . 2006Natur.439..811T .