(6-4)DNA photolyase explained

(6-4)DNA photolyase
Ec Number:	4.1.99.13
Cas Number:	37290-70-3

(6-4)DNA photolyase (DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.^{[1] [2]} This enzyme catalyses the following chemical reaction

(6-4) photoproduct (in DNA)

\rightleftharpoons 2 pyrimidine residues (in DNA)

This enzyme is a flavoprotein.

Notes and References

1. Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED. Elizabeth D. Getzoff . Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes . Proceedings of the National Academy of Sciences of the United States of America . 106 . 17 . 6962–7 . April 2009 . 19359474 . 2678464 . 10.1073/pnas.0809180106 . 2009PNAS..106.6962H . free .
2. Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S . Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase . The Journal of Biological Chemistry . 282 . 7 . 4738–47 . February 2007 . 17164245 . 10.1074/jbc.m604734200 . free .