(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase explained

(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
Ec Number:	1.3.1.53
Cas Number:	162032-77-1
Go Code:	0047120

In enzymology, a (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase is an enzyme that catalyzes the chemical reaction

(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD

\rightleftharpoons 3,4-dihydroxybenzoate + CO + NADH

Thus, the two substrates of this enzyme are (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate and NAD, whereas its 3 products are 3,4-dihydroxybenzoate, CO, and NADH.

This enzyme is a part of the terephthalate degradation pathway in bacteria.^[1]

Family

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase. Another name in common use is (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase. This enzyme employs one cofactor, iron.

References

• Saller E, Laue HR, Schlafli Oppenberg HR, Cook AM . 1996 . Purification and some properties of (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase from Comamonas testosteroni T-2 . FEMS Microbiol. Lett. . 130 . 97 - 102 . 10.1111/j.1574-6968.1995.tb07705.x. free .

Notes and References

1. Web site: National Center for Biotechnology Information. PubChem Enzyme Summary for Enzyme 1.3.1.53. live. https://web.archive.org/web/20200915003956/https://pubchem.ncbi.nlm.nih.gov/protein/EC:1.3.1.53 . 2020-09-15 . 2020-07-30. pubchem.ncbi.nlm.nih.gov. en.