(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase explained

(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
Ec Number:1.13.11.80
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(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (DpgC) is an enzyme[1] catalyses the following chemical reaction

(3,5-dihydroxyphenyl)acetyl-CoA + O 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA.

This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate.

Notes and References

  1. Fielding EN, Widboom PF, Bruner SD . Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC . Biochemistry . 46 . 49 . 13994–4000 . December 2007 . 18004875 . 10.1021/bi701148b .

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