(2,3-dihydroxybenzoyl)adenylate synthase explained

(2,3-dihydroxybenzoyl)adenylate synthase
Ec Number:	2.7.7.58
Cas Number:	122332-73-4
Go Code:	0008668

In enzymology, a (2,3-dihydroxybenzoyl)adenylate synthase is an enzyme that catalyzes the chemical reaction ATP + 2,3-dihydroxybenzoate

\rightleftharpoons diphosphate + (2,3-dihydroxybenzoyl)adenylate.^[1]

Thus, the two substrates of this enzyme are ATP and 2,3-dihydroxybenzoate, whereas its two products are diphosphate and (2,3-dihydroxybenzoyl)adenylate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:2,3-dihydroxybenzoate adenylyltransferase. This enzyme is also called 2,3-dihydroxybenzoate-AMP ligase. This enzyme participates in biosynthesis of siderophore group nonribosomal.

Notes and References

1. Rusnak F, Faraci WS, Walsh CT . Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product . Biochemistry . 28 . 17 . 6827–6835 . August 1989 . 2531000 . 10.1021/bi00443a008 .