(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase explained

(2,2,3-Trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
Ec Number:	6.2.1.38

(2,2,3-Trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase (2-oxo-Delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase) is an enzyme with systematic name ((1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetate:CoA ligase (AMP-forming).^[1] This enzyme catalyses the following chemical reaction

[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate + ATP + CoA

\rightleftharpoons AMP + diphosphate + [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA

This enzyme is isolated from Pseudomonas putida.

Notes and References

1. Ougham HJ, Taylor DG, Trudgill PW . Camphor revisited: involvement of a unique monooxygenase in metabolism of 2-oxo-Δ³-4,5,5-trimethylcyclopentenylacetic acid by Pseudomonas putida . Journal of Bacteriology . 153 . 1 . 140–52 . January 1983 . 6848481 . 217351 .