(−)-menthol monooxygenase explained

(−)-menthol monooxygenase
Ec Number:	1.14.13.46
Cas Number:	117590-75-7
Go Code:	0047505

In enzymology, a (−)-menthol monooxygenase is an enzyme that catalyzes the chemical reaction

(−)-menthol + NADPH + H + O

\rightleftharpoons p-menthane-3,8-diol + NADP + HO

The 4 substrates of this enzyme are (−)-menthol, NADPH, H, and O, whereas its 3 products are p-menthane-3,8-diol, NADP, and HO.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.

Uses

Use of (−)-menthol monooxygenase has been explored by several companies including Procter & Gamble for cleaning products.^{[1] [2] [3]}

References

• Madyastha KM, Srivatsan V . 1988 . Studies on the metabolism of l-menthol in rats . Drug Metab. Dispos. . 16 . 765–72 . 2906604 . 5 .

Notes and References

1. "Cleaning compositions comprising a specific oxygenase"|Alfons, Ivan Maurice et al.|https://patents.google.com/patent/EP1002040B2/en
2. "Methods for conducting assays for enzyme activity on protein microarrays"|Zhou, Fang X.; Schweitzer, Barry| https://patents.google.com/patent/US7635572B2/en?oq=US7635572B2
3. "Cleaning compositions contain a specific oxygenase"|Barnabas, Mary et al.|https://patents.google.com/patent/DE69727704T3/en