(−)-Isopiperitenone reductase explained

(−)-isopiperitenone reductase
Ec Number:	1.3.1.82

(−)-Isopiperitenone reductase is an enzyme with systematic name (+)-cis-isopulegone:NADP⁺ oxidoreductase.^{[1] [2]} It catalyses the following chemical reaction:

(+)-cis-isopulegone + NADP⁺

\rightleftharpoons (−)-isopiperitenone + NADPH + H⁺

The reaction occurs in the opposite direction.

Notes and References

1. Croteau R, Venkatachalam KV . Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita) . Archives of Biochemistry and Biophysics . 249 . 2 . 306–15 . September 1986 . 3755881 . 10.1016/0003-9861(86)90007-x .
2. Ringer KL, McConkey ME, Davis EM, Rushing GW, Croteau R . Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint . Archives of Biochemistry and Biophysics . 418 . 1 . 80–92 . October 2003 . 13679086 . 10.1016/s0003-9861(03)00390-4 .