(+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) explained

(+)-α-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
Ec Number:	4.2.3.50

(+)-α-Santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) (EC 4.2.3.50, SBS) is an enzyme with systematic name (2Z,6Z)-farnesyl diphosphate lyase (cyclizing; (+)-α-santalene-forming).^[1] This enzyme catalyses the following chemical reaction

(2Z,6Z)-farnesyl diphosphate

\rightleftharpoons (+)-α-santalene + diphosphate

The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate.

Notes and References

1. Sallaud C, Rontein D, Onillon S, Jabès F, Duffé P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A . A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites . The Plant Cell . 21 . 1 . 301–17 . January 2009 . 19155349 . 10.1105/tpc.107.057885 . 2648096.