(+)-Pulegone reductase explained

(+)-pulegone reductase
Ec Number:	1.3.1.81

(+)-pulegone reductase is an enzyme with systematic name (−)-menthone:NADP⁺ oxidoreductase.^[1] This enzyme catalises the following chemical reaction

(1) (−)-menthone + NADP⁺

\rightleftharpoons (+)-pulegone + NADPH + H⁺

(2) (+)-isomenthone + NADP⁺

\rightleftharpoons (+)-pulegone + NADPH + H⁺

NADH cannot replace NADPH as reductant.

Notes and References

1. Ringer KL, McConkey ME, Davis EM, Rushing GW, Croteau R . Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint . Archives of Biochemistry and Biophysics . 418 . 1 . 80–92 . October 2003 . 13679086 . 10.1016/s0003-9861(03)00390-4 .