(+)-Larreatricin hydroxylase explained

(+)-Larreatricin hydroxylase
Ec Number:	1.14.99.47

(+)-Larreatricin hydroxylase is an enzyme with systematic name (+)-larreatricin:oxygen 3'-hydroxylase.^[1] This enzyme catalyses the following chemical reaction

(+)-larreatricin + O₂ + AH₂

\rightleftharpoons (+)-3'-hydroxylarreatricin + A + H₂O

This enzyme is isolated from the plant Larrea tridentata (creosote bush) and can be produced recombinantly.^[2]

Notes and References

1. Cho MH, Moinuddin SG, Helms GL, Hishiyama S, Eichinger D, Davin LB, Lewis NG . (+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush (Larrea tridentata) . Proceedings of the National Academy of Sciences of the United States of America . 100 . 19 . 10641–6 . September 2003 . 12960376 . 196857 . 10.1073/pnas.1934562100 . 2003PNAS..10010641C . free .
2. Martin HJ, Kampatsikas I, Oost R, Pretzler M, Al-Sayed E, Roller A, Giester G, Rompel A, Maulide N . 6 . Total Synthesis, Stereochemical Assignment, and Divergent Enantioselective Enzymatic Recognition of Larreatricin . Chemistry: A European Journal . 24 . 59 . 15756–15760 . October 2018 . 30113748 . 6220842 . 10.1002/chem.201803785 .