(+)-Caryolan-1-ol synthase explained

(+)-Caryolan-1-ol synthase
Ec Number:	4.2.1.138

(+)-Caryolan-1-ol synthase (GcoA) is an enzyme with systematic name (+)-β-caryophyllene hydrolase (cyclizing, (+)-caryolan-1-ol-forming).^[1] This enzyme catalyses the following chemical reaction

(+)-β-caryophyllene + H₂O

\rightleftharpoons (+)-caryolan-1-ol

This enzyme also forms (+)-β-caryophyllene from farnesyl diphosphate .

Notes and References

1. Nakano C, Horinouchi S, Ohnishi Y . Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus . The Journal of Biological Chemistry . 286 . 32 . 27980–7 . August 2011 . 21693706 . 3151043 . 10.1074/jbc.m111.265652 . free .