π Lupi (Latinised to Pi Lupi) is a multiple star system in the southern constellation Lupus. Two components form a wide binary pair with an orbital period of 517 years and a semimajor axis of 1.59″. They belong to the Upper Centaurus Lupus component of the Sco–Cen complex.
At least one of the components is a spectroscopic binary and produces eclipses 15.5 days apart, making it an eclipsing binary. There are also other brightness variations with a period of 16 hours that are likely to be pulsations of the Slowly pulsating B-type star. The eclipses are shallow, with the brightness dropping by only 1% or about 0.01 magnitudes. The amplitude of the pulsations is even smaller.
π Lupi A (HR 5605, HD 133242) has been classified as a spectroscopic binary by at least two studies, but both components may be spectroscopic binaries.