4-Pyrone Explained

4-Pyrone (γ-pyrone or pyran-4-one) is an unsaturated cyclic chemical compound with the molecular formula C₅H₄O₂.It is isomeric with 2-pyrone.

Preparation

4-Pyrone is prepared via the thermal decarboxylation of chelidonic acid.^[1]

Reactions

4-Pyrone and its derivatives react with amines in protic solvents to form 4-Pyridones.^{[2] [3]}

Derivatives

4-Pyrone forms the central core of several natural chemical compounds,^[4] including maltol, meconic acid, kojic acid, and of the important class of the Flavones.

See also

• Pyrone
• 4-Pyridone
• Dehydroacetic acid

References

1. Book: Weygand. Conrad. Hilgetag. G.. Martini. A.. Weygand/Hilgetag Preparative Organic Chemistry. 1972. John Wiley & Sons, Inc.. New York. 0471937495. 533–534, & 1009. 4th.
2. Van Allan. J. A.. Reynolds. G. A.. Alessi. J. T.. Chie Chang. S.. C. Joines. R.. Reactions of 4-pyrones with primary amines. A new class of ionic associates. Journal of Heterocyclic Chemistry. 1971. 8. 6. 919–922. 10.1002/jhet.5570080606.
3. Cook. Denys. The Preparation, Properties, and Structure of 2,6-bis-(Alkyamino)-2,5-heptadien-4-ones. Canadian Journal of Chemistry. 1963. 41. 6. 1435–1440. 10.1139/v63-195.
4. 10.1016/j.bmc.2008.11.001. Γ-Pyrone natural products—A privileged compound class provided by nature . 2009 . Wilk . Wolfram . Waldmann . Herbert . Kaiser . Markus . Bioorganic & Medicinal Chemistry . 17 . 6 . 2304–2309 . 19042133 .