Β-Ketoisocaproic acid explained

β-Ketoisocaproic acid, also known as 4-methyl-3-oxopentanoic acid, is an intermediate in the metabolism of leucine.^{[1] [2]} Its metabolic precursor and metabolic product in the leucine metabolic pathway are and β-ketoisocaproyl-CoA, respectively.

Notes and References

1. Book: Kohlmeier M . Nutrient Metabolism: Structures, Functions, and Genes . May 2015 . Academic Press . 978-0-12-387784-0 . pp. 385–388, Figure 8.57 . 2nd . https://books.google.com/books?id=aTQTAAAAQBAJ&q=beta-hydroxy%20beta-methylbutyrate%20HMB&pg=PA387 . 6 June 2016 . Leucine . Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds ...
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2. Web site: Leucine metabolism. BRENDA. Technische Universität Braunschweig. 12 August 2016. https://web.archive.org/web/20160817213425/http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg. 17 August 2016.