Α-PHiP explained

α-Pyrrolidinoisohexanophenone (mainly known as A-PiHP or α-PiHP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potency in vitro as an inhibitor of the dopamine transporter of the alpha substituted derivatives tested.^[1] α-PiHP acts as a norepinephrine–dopamine reuptake inhibitor. Compared to α-PVP and α-PHP, α-PiHP displays a higher selectivity for the dopamine transporter. Similar to other cathinones, use of α-PiHP can result in compulsive redosing, addiction, anxiety, paranoia, and psychosis. In July 2016 α-PHiP was first identified as a designer drug^[2] when it was reported to the EMCDDA by a forensic laboratory in Slovenia.^{[3] [4]}

See also

• 3F-PiHP
• Aletamine
• α-PHP
• α-PCYP
• Solriamfetol

Notes and References

1. Meltzer PC, Butler D, Deschamps JR, Madras BK . 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors . Journal of Medicinal Chemistry . 49 . 4 . 1420–32 . February 2006 . 16480278 . 2602954 . 10.1021/jm050797a .
2. Web site: Analytic Report alpha-PHiP (C16H23NO) 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one. . Nacionalni forenzični laboratorij . Slovenia . July 2016 . 2019-10-24 . 2020-10-03 . https://web.archive.org/web/20201003004736/https://www.policija.si/apps/nfl_response_web/0_Analytical_Reports_final/alpha-PHiP-ID-1723-16rpt071216.pdf . live .
3. Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA . EMCDDA–Europol Joint Publication . 2019-10-24 . 2021-01-26 . https://web.archive.org/web/20210126100454/https://www.emcdda.europa.eu/system/files/publications/4724/TDAN17001ENN_PDFWEB.pdf . live .
4. Liu C, Jia W, Li T, Hua Z, Qian Z . Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α-EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, α-PiHP, 4-Cl-α-PHP, and 4-F-α-PHP . Drug Testing and Analysis . 9 . 8 . 1162–1171 . August 2017 . 27863142 . 10.1002/dta.2136 .