Α-N-Acetylglucosaminidase Explained
| α-N-acetylglucosaminidase |
| Caption: | Human α-N-acetylglucosaminidase coloured by domain.[1] |
| Hgncid: | 7632 |
| Symbol: | NAGLU |
| Entrezgene: | 4669 |
| Omim: | 609701 |
| Refseq: | NM_000263 |
| Uniprot: | P54802 |
| Ecnumber: | 3.2.1.50 |
| Chromosome: | 17 |
| Arm: | q |
| Band: | 11 |
| Locussupplementarydata: | -q21 |
The enzyme α-N-acetylglucosaminidase (α-acetylglucosaminidase, N-acetyl-α-D-glucosaminidase, N-acetyl-α-glucosaminidase, α-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome, with systematic name α-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase.[2] [3] [4] [5] It catalyses the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-α-D-glucosaminides, and also UDP-N-acetylglucosamine.
Notes and References
- Birrane . Gabriel . Dassier . Anne-Laure . Romashko . Alla . Lundberg . Dianna . Holmes . Kevin . Cottle . Thomas . Norton . Angela W. . Zhang . Bohong . Concino . Michael F. . Meiyappan . Muthuraman . 2019 . Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B . Journal of Structural Biology . en . 205 . 3 . 65–71 . 10.1016/j.jsb.2019.02.005. 30802506 . 73482664 . free .
- von Figura K . Human α-N-acetylglucosaminidase. 1. Purification and properties . European Journal of Biochemistry . 80 . 2 . 523–533 . November 1977 . 411658 . 10.1111/j.1432-1033.1977.tb11908.x . free .
- von Figura K . Human α-N-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms . European Journal of Biochemistry . 80 . 2 . 535–542 . November 1977 . 923593 . 10.1111/j.1432-1033.1977.tb11909.x . free .
- Weissmann B, Rowin G, Marshall J, Friederici D . Mammalian α-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization . Biochemistry . 6 . 1 . 207–214 . January 1967 . 4291567 . 10.1021/bi00853a033 .
- Werries E, Wollek E, Gottschalk A, Buddecke E . Separation of N-acetyl-α-glucosaminidase and N-acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-α-galactosaminidase . European Journal of Biochemistry . 10 . 3 . 445–449 . October 1969 . 5348072 . 10.1111/j.1432-1033.1969.tb00709.x . free .
