| École secondaire catholique Saint-Frère-André | |
| Address: | 330 Lansdowne Avenue |
| Country: | Canada |
| Coordinates: | 43.6522°N -79.441°W |
| Motto: | L'élève au cœur de l'excellence |
| Motto Translation: | Students at the heart of excellence |
| Founded: | 2012 |
| Superintendent: | André Blais |
| Trustee: | Reno-Claude D'Aigle |
| Number: | 691950 |
| Principal: | Mark Arseneau |
| Grades: | 7-12 |
École secondaire catholique Saint-Frère-André is a French-language Roman Catholic high school in Toronto, Ontario, Canada.
The school is operated by Conseil scolaire catholique MonAvenir. It occupies part of the former West Toronto Collegiate building, which it shares with École secondaire Toronto Ouest, a public French-language high school operated by Conseil scolaire Viamonde. Saint-Frère-André is also a high school that accepts students from the 7th and 8th grade.